Predominant Promotion by Tacrolimus of Chondrogenic Differentiation to Proliferating Chondrocytes
Tacrolimus (FK506) has been used as a therapeutic drug beneficial for the treatment of rheumatoid arthritis in humans.In this study, we investigated the effects of FK506 on cellular differentiation in cultured chondrogenic cells.Culture with FK506 led to a significant and concentration-dependent increase in Alcian blue staining for matrix proteogly